A Mixed-Effects Model for Powerful Association Tests in Integrative Functional Genomics
نویسندگان
چکیده
منابع مشابه
More powerful genetic association testing via a new statistical framework for integrative genomics.
Integrative genomics offers a promising approach to more powerful genetic association studies. The hope is that combining outcome and genotype data with other types of genomic information can lead to more powerful SNP detection. We present a new association test based on a statistical model that explicitly assumes that genetic variations affect the outcome through perturbing gene expression lev...
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15 صفحه اولWeb - based Supplementary Materials for “ More powerful genetic association testing via a new statistical framework for integrative genomics ”
In Section 3 we showed that our method can have more power to detect o-eSNPs. Here we discuss its power to detect SNPs whose functional mechanisms have non-regulatory components. For simplicity we again consider only continuous Yi, Gi, and a single SNP Si in the ordinary linear model, where the variables have all been centered. We now consider the outcome model Yi = G T i αG + αSSi + i1, where ...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2018
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2018.03.019